Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 6/20 | 0.32 |
| ▸ | RARB | P10826 | 6/20 | 0.32 |
| ▸ | RARG | P13631 | 6/20 | 0.32 |
| ▸ | RARA | P10276 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | RXRB | P28702 | 2/20 | 0.32 |
| ▸ | RXRG | P48443 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522730 | 1.00 | RBP4 (0.33) | RBP4RXRARARBRARGRARA | |
| SCHEMBL8460516 | 0.67 | RXRA (0.30) | RXRARARBRARGRARAALDH1A1 | |
| SCHEMBL8460520 | 0.67 | RXRA (0.30) | RXRARARBRARGRARAALDH1A1 | |
| SCHEMBL10799157 | 0.66 | ALDH1A1 (0.70) | RBP4RXRARARBRARGRARA | |
| SCHEMBL6037056 | 0.63 | RXRA (0.34) | RXRARARBRARGRARARXRB | |
| SCHEMBL6037052 | 0.63 | RXRA (0.34) | RXRARARBRARGRARARXRB | |
| SCHEMBL9096736 | 0.61 | LDHA (0.42) | ALDH1A1MAPTPTGS1KDM4EPGR | |
| SCHEMBL20165832 | 0.58 | ALDH1A1 (0.37) | RBP4RXRARARBRARGRARA | |
| SCHEMBL14465843 | 0.57 | GRIK1 (0.37) | KDM4ERECQL | |
| SCHEMBL23052821 | 0.56 | ALDH1A1 (0.61) | RBP4RXRARARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |