Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29746320 | 0.84 | PDK1 (0.48) | PDK1PDK2PDK3PDK4TSHR | |
| SCHEMBL8522803 | 0.81 | PDK1 (0.46) | PDK1PDK2PDK3PDK4TSHR | |
| SCHEMBL29746522 | 0.76 | RIPK1 (0.45) | PDK1PDK2PDK3PDK4ACE | |
| SCHEMBL16036390 | 0.76 | MEN1 (0.43) | PDK1PDK2PDK3PDK4TSHR | |
| SCHEMBL26613362 | 0.76 | RIPK1 (0.45) | PDK1PDK2PDK3PDK4ACE | |
| SCHEMBL13305787 | 0.75 | CHRNB2 (0.44) | TSHRPKMHPGDNPSR1MAPK1 | |
| SCHEMBL8554748 | 0.75 | TSHR (0.42) | TSHRPKMHPGDNPSR1GAA | |
| SCHEMBL10683163 | 0.75 | CHRNB2 (0.44) | TSHRPKMHPGDNPSR1MAPK1 | |
| SCHEMBL8522620 | 0.74 | MTNR1A (0.47) | GAASMN1; SMN2ACEL3MBTL1POLB | |
| SCHEMBL11765796 | 0.73 | TSHR (0.48) | TSHRPKMHPGDNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996024587-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1996-08-15 | — | — | WO | claimed |
| EP-0907374-A1 | GROWTH HORMONE COMPONENT AND BONE ANTI-RESORPTIVE AGENT IN CYCLIC (COHERENCE) TREATMENT OF OSTEOPOROSIS | NOVO NORDISK A/S (DK) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997046252-A1 | GROWTH HORMONE COMPONENT AND BONE ANTI-RESORPTIVE AGENT IN CYCLIC (COHERENCE) TREATMENT OF OSTEOPOROSIS | NOVO NORDISK A/S (DK) | 1997-12-11 | — | — | WO | disclosed |
| WO-1996024587-A1 | COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES | NOVO NORDISK A/S (DK) | 1996-08-15 | — | — | WO | disclosed |