SCHEMBL8523228

SCHEMBL8523228

CSc1c(C)c(-c2nccc(Cl)c2F)nn1C

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 7/20 0.34
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7687299 0.73 GRM5 (0.35) GRM5POLB
SCHEMBL8022013 0.70 POLB (0.32) POLB
SCHEMBL8031860 0.69 HSD11B1 (0.40) GRM5
SCHEMBL8031277 0.69 HSD11B1 (0.47)
SCHEMBL8035641 0.69 HSP90AA1 (0.34)
SCHEMBL14039836 0.64 MAPK14 (0.43) POLB
SCHEMBL16273639 0.64 ESR2 (0.40) POLB
SCHEMBL30761229 0.62
SCHEMBL1507127 0.62
SCHEMBL14974820 0.61 KMO (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0966461-A1 PYRAZOLE DERIVATIVES AS HERBICIDES Novartis AG (CH) 1999-12-29 EP disclosed
WO-1998042698-A1 PYRAZOLE DERIVATIVES AS HERBICIDES NOVARTIS AG (CH) 1998-10-01 WO disclosed