Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 8/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522571 | 0.81 | ADORA3 (0.47) | RAB9AMAPTPARP1ADORA3 | |
| SCHEMBL8523766 | 0.77 | KDM4E (0.39) | DHODHSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4057758 | 0.70 | RAB9A (0.51) | DHODHSMN1; SMN2NPC1RAB9AALDH1A1 | |
| Water SCHEMBL8326247 | 0.69 | ESR2 (0.33) | DHODHSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4059604 | 0.64 | RAB9A (0.55) | DHODHSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL8324852 | 0.63 | GAA (0.53) | SMN1; SMN2NPC1RAB9ALMNAADORA3 | |
| SCHEMBL5324211 | 0.62 | SMN1; SMN2 (0.71) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL23400622 | 0.61 | LMNA (0.54) | SMN1; SMN2NPC1RAB9ATP53MAPT | |
| SCHEMBL22093797 | 0.60 | MAT2A (0.80) | MAPTALDH1A1LMNADHFR | |
| SCHEMBL31145413 | 0.60 | MAT2A (0.80) | MAPTALDH1A1LMNADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888347-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1999-01-07 | — | — | EP | claimed |
| WO-1997034893-A1 | PHARMACEUTICALLY USEFUL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-09-25 | — | — | WO | claimed |