Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKLR | P30613 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525044 | 0.90 | PKLR (0.49) | MEN1KMT2APKLRALDH1A1EGLN1 | |
| SCHEMBL8524542 | 0.87 | F2 (0.49) | MEN1KMT2AKLKB1ALDH1A1 | |
| SCHEMBL8524454 | 0.84 | PKLR (0.49) | MEN1KMT2APKLRALDH1A1EGLN1 | |
| SCHEMBL8525447 | 0.84 | PKLR (0.44) | PKLRMCL1CNR2 | |
| SCHEMBL1110102 | 0.78 | TUBB (0.46) | MCL1KLKB1KLK1CNR2AKR1B1 | |
| SCHEMBL7358688 | 0.78 | PKLR (0.47) | MEN1KMT2APKLRALDH1A1EGLN1 | |
| Hydrochloric Acid SCHEMBL8525302 | 0.77 | F2 (0.56) | MEN1KMT2APKLRALDH1A1 | |
| SCHEMBL8525757 | 0.77 | KMT2A (0.44) | MEN1KMT2APKLRALDH1A1EGLN1 | |
| SCHEMBL8525059 | 0.75 | HDAC2 (0.46) | KLKB1KLK1CNR2IMPDH2CTNNB1 | |
| SCHEMBL8525755 | 0.73 | HSP90AA1 (0.49) | MCL1CNR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999029670-A2 | AMINOCARBONYLTETRALIN AND DIHYDRONAPHTALENE DERIVATES AS THROMBIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-06-17 | — | — | WO | disclosed |