SCHEMBL8524767

SCHEMBL8524767

C=CCN1CNc2cc(OC)ccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.40
ALDH1A1 P00352 2/20 0.37
TP53 P04637 2/20 0.37
ALOX15 P16050 2/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
ALOX12 P18054 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 2/20 0.36
GFER P55789 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
HTR3E A5X5Y0 1/20 0.36
HTR3B O95264 1/20 0.36
HTR3A P46098 1/20 0.36
HTR3D Q70Z44 1/20 0.36
HTR3C Q8WXA8 1/20 0.36
PDE4B Q07343 2/20 0.36
MAPK1 P28482 2/20 0.36
GLA P06280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20888870 0.83 HTR3E (0.39) ALDH1A1SMN1; SMN2KDM4EHTR3EHTR3B
SCHEMBL8523710 0.77 SCN9A (0.39) ALDH1A1CYP3A4KDM4ENPC1HTR3E
SCHEMBL8523950 0.77 GRIA2 (0.37) ALDH1A1KDM4ETDP1GAAGRIA1
SCHEMBL9480519 0.77 HRH3 (0.40) HRH3ALDH1A1TP53ALOX15CYP3A4
SCHEMBL8523029 0.73 DRD2 (0.37) ALDH1A1SMN1; SMN2KDM4EHPGDGRIA1
SCHEMBL10863167 0.73 NPY5R (0.44) HRH3NPC1TNFRSF1A
SCHEMBL7544166 0.73 GAA (0.42) ALDH1A1KDM4ETDP1L3MBTL1HSD17B10
SCHEMBL10816704 0.71 HSD17B10 (0.51) HRH3TP53HSD17B10
SCHEMBL8469923 0.70 GRIA1 (0.44) ALDH1A1CYP3A4KDM4EHPGDGRIA1
SCHEMBL9316153 0.70 GAA (0.39) ALDH1A1TSHRSMN1; SMN2KDM4EMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5968725-A MATERIAL COMPRISING ON SUPPORT SILVER HALIDE PHOTOSENSITIVE LAYER CONTAINING ORGANIC SILVER SALT, REDUCING AGENT, ULTRAHIGH CONTRAST PROMOTING AGENT, SELECTED HETEROCYCLIC MERCAPTO COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1999-10-19 US disclosed
US-5236807-A Negative, hydrazine compound FUJI PHOTO FILM CO., LTD. (JP) 1993-08-17 US disclosed
US-4769316-A Method for restraining the formation of re-reversal negative image in direct positive silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1988-09-06 US disclosed