Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MC5R | P33032 | 6/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
| ▸ | MC1R | Q01726 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525511 | 0.85 | NAMPT (0.57) | NAMPTCYP2D6CHRM1HTR2AMCHR1 | |
| SCHEMBL8581380 | 0.82 | KMT2A (0.48) | NAMPTHIF1ACNR1TP53POLB | |
| SCHEMBL8524910 | 0.81 | NAMPT (0.64) | NAMPTSMN1; SMN2 | |
| SCHEMBL8523428 | 0.80 | NAMPT (0.60) | NAMPT | |
| SCHEMBL3706441 | 0.80 | NAMPT (1.00) | NAMPT | |
| SCHEMBL8395266 | 0.79 | ALDH1A1 (0.59) | NAMPTTP53MAPTCYP2D6CHRM1 | |
| SCHEMBL8583853 | 0.78 | HIF1A (0.57) | NAMPTHIF1ATRPV1TP53POLB | |
| SCHEMBL8396226 | 0.78 | ALDH1A1 (0.56) | NAMPTTP53MAPT | |
| SCHEMBL5598218 | 0.76 | HIF1A (0.85) | NAMPTHIF1ACNR1TRPV1MAPT | |
| SCHEMBL8160653 | 0.75 | HIF1A (1.00) | NAMPTHIF1ATRPV1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |