Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MLYCD | O95822 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523428 | 0.97 | NAMPT (0.60) | NAMPTNPC1RAB9AMLYCDHSP90AA1 | |
| SCHEMBL8525511 | 0.93 | NAMPT (0.57) | NAMPTNPC1RAB9A | |
| SCHEMBL8394079 | 0.88 | NPC1 (0.54) | NAMPTNPC1RAB9ASMN1; SMN2F10 | |
| Hydrochloric Acid SCHEMBL8395526 | 0.87 | NPC1 (0.53) | NAMPTNPC1RAB9ASMN1; SMN2F10 | |
| SCHEMBL8396226 | 0.86 | ALDH1A1 (0.56) | NAMPTRAB9A | |
| SCHEMBL8392756 | 0.85 | KMT2A (0.53) | NAMPTNPC1RAB9ASMN1; SMN2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL8394145 | 0.84 | KMT2A (0.53) | NAMPTNPC1RAB9ASMN1; SMN2HSP90AA1 | |
| SCHEMBL8581485 | 0.82 | HPGD (0.54) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8395266 | 0.82 | ALDH1A1 (0.59) | NAMPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8394017 | 0.81 | LMNA (0.58) | NAMPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | disclosed |