Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL2485034 | 0.84 | OTC (0.40) | KIF11OTCPOLBKMT2ATDP1 | |
| Arginine SCHEMBL4728793 | 0.84 | OTC (0.40) | KIF11OTCPOLBKMT2ATDP1 | |
| Arginine SCHEMBL16553180 | 0.84 | SLC1A3 (0.45) | ALDH1A1CYP3A4HSD17B10KIF11ITGB3 | |
| Arginine SCHEMBL16553181 | 0.84 | SLC1A3 (0.45) | ALDH1A1CYP3A4HSD17B10KIF11ITGB3 | |
| Arginine SCHEMBL28268971 | 0.83 | OTC (0.53) | CYP3A4TSHROTCNOS3NOS1 | |
| Arginine SCHEMBL27833904 | 0.82 | OTC (0.41) | KIF11OTCEGLN2NOS3NOS1 | |
| SCHEMBL6553039 | 0.82 | TGM2 (0.45) | ITGB3ITGA2B | |
| Arginine SCHEMBL28206848 | 0.82 | ALDH1A1 (0.41) | ALDH1A1CYP3A4HSD17B10KIF11OTC | |
| Arginine SCHEMBL26914670 | 0.82 | KIF11 (0.46) | KIF11OTCEGLN2POLBKMT2A | |
| Arginine SCHEMBL28968817 | 0.81 | KYNU (0.49) | OTCNOS3NOS1NOS2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906418-A4 | — | — | 1999-05-06 | — | — | EP | disclosed |
| EP-0906418-A1 | METHODS AND COMPOSITIONS FOR CELLULAR AND METABOLIC ENGINEERING | Maxygen, Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997035966-A1 | METHODS AND COMPOSITIONS FOR CELLULAR AND METABOLIC ENGINEERING | MAXYGEN, INC. (US) | 1997-10-02 | — | — | WO | disclosed |