Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688845 | 0.75 | C5AR1 (0.38) | HPGDKDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL13518094 | 0.73 | NFE2L2 (0.56) | HPGDALDH1A1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL8525313 | 0.73 | ALDH1A1 (0.43) | PTPN1HPGDKDM4EALDH1A1TDP1 | |
| SCHEMBL1688846 | 0.72 | CRHR1 (0.40) | HPGDKDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL9325584 | 0.70 | NFE2L2 (0.41) | HPGDALDH1A1KMT2ANFE2L2TGM2 | |
| SCHEMBL13518614 | 0.70 | MEN1 (0.49) | HPGDKMT2ASMN1; SMN2NFE2L2TGM2 | |
| SCHEMBL10430614 | 0.69 | ACHE (0.48) | HPGDKDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL27987937 | 0.68 | SMN1; SMN2 (0.39) | PTPN1KDM4EALDH1A1ALOX5SMN1; SMN2 | |
| SCHEMBL28823022 | 0.66 | TSHR (0.57) | PTPN1KDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL28360720 | 0.66 | KDM4E (0.36) | HPGDKDM4EALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977075-A | N-aroylamino acid amides as endothelin inhibitors | NOVARTIS AG (CH) | 1999-11-02 | — | — | US | disclosed |
| EP-0821670-A1 | N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS | Novartis AG (CH) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033170-A1 | N-AROYLAMINO ACID AMIDES AS ENDOTHELIN INHIBITORS | NOVARITS AG (CH) | 1996-10-24 | — | — | WO | disclosed |