Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076486 | 0.82 | GAA (0.48) | HTTALDH1A1GAAPKM | |
| SCHEMBL6027840 | 0.70 | HTT (0.37) | HTTALDH1A1GAA | |
| SCHEMBL7559774 | 0.70 | HTT (0.35) | HTTALDH1A1GAA | |
| SCHEMBL29034906 | 0.69 | KMT2A (0.46) | HTTALDH1A1RXRARXRBL3MBTL1 | |
| SCHEMBL4393026 | 0.66 | THRB (0.55) | RXRARXRBAPPCA1CA2 | |
| SCHEMBL9280835 | 0.66 | HTT (0.43) | HTTALDH1A1GAA | |
| SCHEMBL29098238 | 0.66 | THRB (0.39) | HTTALDH1A1GAAL3MBTL1PKM | |
| Iodobenzene SCHEMBL28964206 | 0.64 | PAM (0.44) | HTTALDH1A1GAATPMT | |
| SCHEMBL3156584 | 0.64 | ALDH1A1 (0.39) | HTTALDH1A1GAAL3MBTL1 | |
| SCHEMBL5323455 | 0.64 | KMT2A (0.44) | HTTRXRARXRBL3MBTL1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999014204-A1 | SUBSTITUTED 1,2,4-TRIAZOLES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | G.D. SEARLE & CO. (US) | 1999-03-25 | — | — | WO | disclosed |