Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527036 | 0.82 | FAAH (0.46) | MGLLMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8525857 | 0.75 | HTR2B (0.40) | MEN1KMT2AALDH1A1POLBPKM | |
| SCHEMBL8526108 | 0.73 | ALDH1A1 (0.42) | ALDH1A1KDM4EPABPC1CMA1 | |
| SCHEMBL8527235 | 0.71 | KMT2A (0.46) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10569729 | 0.67 | KMT2A (0.46) | MGLLMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL30457623 | 0.65 | MEN1 (0.77) | MGLLMEN1KMT2AHTTMAPT | |
| SCHEMBL8526950 | 0.63 | KMT2A (0.41) | MGLLMEN1KMT2AHTTMAPT | |
| SCHEMBL11543595 | 0.62 | KMT2A (0.62) | MGLLMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28494976 | 0.62 | KMT2A (0.58) | MGLLMEN1KMT2AHTTMAPT | |
| SCHEMBL28933339 | 0.62 | KMT2A (0.61) | MGLLMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | claimed |