Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527235 | 0.92 | KMT2A (0.46) | HTR2BOPRM1HRH2MEN1KMT2A | |
| SCHEMBL8528166 | 0.92 | P2RX7 (0.37) | HTR2BOPRM1HRH2MEN1KMT2A | |
| SCHEMBL8526252 | 0.84 | HTR2B (0.37) | HTR2BOPRM1HRH2MEN1KMT2A | |
| SCHEMBL8528512 | 0.79 | DPP4 (0.39) | MEN1KMT2APABPC1ALDH1A1DPP4 | |
| SCHEMBL8525685 | 0.75 | MGLL (0.41) | MEN1KMT2APABPC1ALDH1A1TP53 | |
| SCHEMBL8528545 | 0.75 | MEN1 (0.42) | HTR2BMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL8526108 | 0.75 | ALDH1A1 (0.42) | HTR2BOPRM1PABPC1ALDH1A1HTR2C | |
| SCHEMBL8527036 | 0.73 | FAAH (0.46) | MEN1KMT2APABPC1GAAALDH1A1 | |
| SCHEMBL8664646 | 0.71 | ALDH1A1 (0.41) | HTR2BOPRM1MEN1KMT2AGAA | |
| SCHEMBL10568980 | 0.67 | ALDH1A1 (0.51) | MEN1KMT2AGAAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | claimed |
| EP-0885197-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032855-A1 | 2-THIOXOTETRAHYDROPYRIMIDIN-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |