Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527910 | 0.91 | DRD2 (0.48) | PRMT5WDR77DRD3DRD2LMNA | |
| Hydrochloric Acid SCHEMBL8528647 | 0.90 | DRD2 (0.47) | PRMT5WDR77DRD3DRD2LMNA | |
| SCHEMBL8526913 | 0.82 | DRD3 (0.58) | DRD3DRD2CYP2D6ADRA2ACYP1A2 | |
| SCHEMBL8527632 | 0.79 | HTT (0.42) | DRD3DRD2ALDH1A1HPGDCYP1A2 | |
| SCHEMBL8967296 | 0.78 | DRD3 (0.51) | DRD3DRD2 | |
| SCHEMBL11399777 | 0.77 | LMNA (0.48) | PRMT5WDR77DRD3DRD2LMNA | |
| Hydrochloric Acid SCHEMBL8967334 | 0.77 | DRD3 (0.51) | DRD3DRD2 | |
| SCHEMBL8526355 | 0.77 | MEN1 (0.66) | DRD3DRD2LMNAALDH1A1KDM4E | |
| SCHEMBL8967277 | 0.76 | ALDH1A1 (0.54) | DRD3DRD2LMNAALDH1A1KDM4E | |
| SCHEMBL8529533 | 0.76 | DRD2 (0.40) | PRMT5WDR77DRD3DRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | claimed |
| US-5498628-A | ANTIPSYCHOTIC, PSYCHOSTIMULATORY, ANTIAUTISTIC, ANTIDEPRESSANT AND HYPOTENSIVE AGENTS, PARKINSON'S DISEASE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-03-12 | — | — | US | disclosed |