Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.62 |
| ▸ | CTSL | P07711 | 9/20 | 0.59 |
| ▸ | CTSK | P43235 | 9/20 | 0.59 |
| ▸ | CTSS | P25774 | 7/20 | 0.57 |
| ▸ | CTSB | P07858 | 2/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048302 | 1.00 | REN (0.62) | RENCTSLCTSKCTSSCTSB | |
| SCHEMBL8528279 | 0.92 | PSEN1 (0.57) | RENCTSLCTSKPSEN1PSEN2 | |
| SCHEMBL3498556 | 0.91 | CTSS (0.64) | RENCTSLCTSKCTSSCTSB | |
| SCHEMBL7295862 | 0.91 | CTSS (0.69) | RENCTSLCTSKCTSSCTSB | |
| SCHEMBL5050550 | 0.91 | CTSS (0.69) | RENCTSLCTSKCTSSCTSB | |
| SCHEMBL7295855 | 0.91 | CTSS (0.69) | RENCTSLCTSKCTSSCTSB | |
| SCHEMBL11599759 | 0.89 | CTSS (0.55) | RENCTSLCTSKCTSSCTSB | |
| SCHEMBL2402235 | 0.86 | CTSS (0.60) | CTSLCTSKCTSSCTSB | |
| SCHEMBL3922795 | 0.86 | CTSS (0.60) | CTSLCTSKCTSSCTSB | |
| SCHEMBL6292769 | 0.86 | CTSS (0.60) | CTSLCTSKCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | claimed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | claimed |
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5514778-A | ENZYME INHIBITORS OF PROTEOLYTIC ENZYMES FOR RHINOVIRUSES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | disclosed |