Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.57 |
| ▸ | REN | P00797 | 5/20 | 0.56 |
| ▸ | CTSD | P07339 | 3/20 | 0.53 |
| ▸ | BACE1 | P56817 | 3/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048302 | 0.92 | REN (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8526673 | 0.92 | REN (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11199973 | 0.92 | CTSS (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8530799 | 0.88 | REN (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8529162 | 0.86 | CTSL (0.55) | CTSLCTSK | |
| SCHEMBL11210637 | 0.85 | CTSS (0.54) | CTSLCTSK | |
| SCHEMBL8530092 | 0.85 | CTSS (0.72) | RENCTSLCTSK | |
| SCHEMBL8530164 | 0.84 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3498556 | 0.83 | CTSS (0.64) | RENCTSLCTSK | |
| SCHEMBL5050550 | 0.83 | CTSS (0.69) | RENCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | claimed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | claimed |
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5514778-A | ENZYME INHIBITORS OF PROTEOLYTIC ENZYMES FOR RHINOVIRUSES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | disclosed |