SCHEMBL8527262

SCHEMBL8527262

CC(=O)On1cnc2c(NC(=O)COc3ccccc3)ncnc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
RAB9A P51151 4/20 0.46
MAPT P10636 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
KDM4E B2RXH2 2/20 0.46
RXFP1 Q9HBX9 1/20 0.46
NPC1 O15118 4/20 0.45
GAA P10253 1/20 0.44
ADORA3 P0DMS8 1/20 0.43
ADORA2B P29275 1/20 0.43
ADORA1 P30542 1/20 0.43
TSHR P16473 3/20 0.43
HSD17B10 Q99714 2/20 0.43
ALPL P05186 1/20 0.43
MAPK10 P53779 1/20 0.43
PDE4A P27815 1/20 0.43
PDE4B Q07343 1/20 0.43
PDE4C Q08493 1/20 0.43
PDE4D Q08499 1/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8527924 0.83 ALDH1A1 (0.46) ALDH1A1RAB9AMAPTSMN1; SMN2KDM4E
SCHEMBL8527256 0.80 TDP1 (0.49) RAB9ASMN1; SMN2NPC1GAAALPL
SCHEMBL5962910 0.72 ADORA3 (0.68) ALDH1A1RAB9ASMN1; SMN2RXFP1NPC1
SCHEMBL5962916 0.72 ADORA3 (0.68) ALDH1A1RAB9ASMN1; SMN2RXFP1NPC1
SCHEMBL6933552 0.71 ALPL (0.52) ALDH1A1RAB9AMAPTSMN1; SMN2KDM4E
SCHEMBL19224316 0.70 ADORA3 (0.61) ALDH1A1RAB9ASMN1; SMN2RXFP1NPC1
SCHEMBL9446435 0.70 SLC29A1 (0.57) ADORA3ADORA1
SCHEMBL7035979 0.70 SLC29A1 (0.57) ADORA3ADORA1
SCHEMBL18776405 0.70 ADORA3 (0.52) ADORA3ADORA2BADORA1MEN1KMT2A
SCHEMBL22458325 0.68 FGFR1 (0.45) ALDH1A1MAPTPDE4APDE4BPDE4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885236-A1 OLIGONUCLEOTIDE ANALOGS Codon Pharmaceuticals, Inc. (US) 1998-12-23 EP disclosed
WO-1997027206-A1 OLIGONUCLEOTIDE ANALOGS CODON PHARMACEUTICALS, INC. (US) 1997-07-31 WO disclosed