SCHEMBL8527427

SCHEMBL8527427

COc1ccc2c(c1)CCC2c1ccc(C(C)=NO)cc1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.43
GID4 Q8IVV7 1/20 0.41
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41
SRD5A1 P18405 2/20 0.39
SLC6A9 P48067 1/20 0.39
HTR2C P28335 1/20 0.39
LMNA P02545 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CHRNA7 P36544 1/20 0.38
MTNR1A P48039 1/20 0.38
MTNR1B P49286 1/20 0.38
DRD2 P14416 1/20 0.38
DRD3 P35462 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8530718 0.85 MTNR1A (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL5709325 0.79 CA1 (0.54) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8530025 0.79 HAO1 (0.45) GID4HTR2C
SCHEMBL8530528 0.77 CYP19A1 (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8821371 0.76 GID4 (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8530379 0.74 CYP19A1 (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8534540 0.73 CYP19A1 (0.44) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8527122 0.73 ADRA2A (0.43) CYP19A1SLC6A2SLC6A4SLC6A3
SCHEMBL8530757 0.71 HAO1 (0.55) GID4LMNA
SCHEMBL30322657 0.71 SMN1; SMN2 (0.65)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739140-A AGRICULTURAL FUNGICIDES MONSANTO COMPANY (US) 1998-04-14 US disclosed
WO-1997016413-A9 ARYL ACRYLICS FOR USE AS FUNGICIDE 1997-08-14 WO disclosed