SCHEMBL8530379

SCHEMBL8530379

COc1ccc2c(c1)CCC2c1ccc(C(C)Br)cc1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.45
GID4 Q8IVV7 1/20 0.43
SLC6A2 P23975 2/20 0.42
SLC6A4 P31645 2/20 0.42
SLC6A3 Q01959 2/20 0.42
SRD5A1 P18405 2/20 0.41
HTR2C P28335 1/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA9 Q16790 2/20 0.40
CA14 Q9ULX7 2/20 0.40
LMNA P02545 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CHRNA7 P36544 1/20 0.40
DRD2 P14416 1/20 0.40
DRD3 P35462 1/20 0.40
CA7 P43166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8530528 0.87 CYP19A1 (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL5709325 0.81 CA1 (0.54) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8534540 0.78 CYP19A1 (0.44) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8527046 0.77 SIGMAR1 (0.46) GID4SLC6A2SLC6A4SLC6A3HTR2C
SCHEMBL8530718 0.76 MTNR1A (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8821371 0.75 GID4 (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8527427 0.74 CYP19A1 (0.43) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL22628673 0.72 CYP24A1 (0.47) CYP19A1HTR2CDRD2
SCHEMBL8938889 0.72 KMT2A (0.52) LMNA
SCHEMBL1144004 0.70 PDE1B (0.47) CYP19A1GID4HTR2CDRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0877730-A1 ARYL ACRYLICS FOR USE AS FUNGICIDE MONSANTO COMPANY (US) 1998-11-18 EP disclosed
US-5739140-A AGRICULTURAL FUNGICIDES MONSANTO COMPANY (US) 1998-04-14 US disclosed
WO-1997016413-A9 ARYL ACRYLICS FOR USE AS FUNGICIDE 1997-08-14 WO disclosed
WO-1997016413-A1 ARYL ACRYLICS FOR USE AS FUNGICIDE MONSANTO COMPANY (US) 1997-05-09 WO disclosed