SCHEMBL8534540

SCHEMBL8534540

COc1ccc2c(c1)CCC2c1ccc(CCBr)cc1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.44
GRIN2B Q13224 5/20 0.43
GRIN1 Q05586 2/20 0.43
GID4 Q8IVV7 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
NPY5R Q15761 1/20 0.41
KDM1A O60341 1/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
SRD5A1 P18405 2/20 0.40
DDB1 Q16531 1/20 0.40
CRBN Q96SW2 1/20 0.40
CYP26A1 O43174 1/20 0.40
SLC6A9 P48067 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8821371 0.87 GID4 (0.45) CYP19A1GRIN2BGRIN1GID4SLC6A2
SCHEMBL5709325 0.80 CA1 (0.54) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8530379 0.78 CYP19A1 (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8821358 0.76 SIGMAR1 (0.42) GRIN2BGID4KDM1AMAOAMAOB
SCHEMBL8530718 0.75 MTNR1A (0.45) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8530528 0.75 CYP19A1 (0.45) CYP19A1GRIN2BGRIN1GID4SLC6A2
SCHEMBL8527427 0.73 CYP19A1 (0.43) CYP19A1GID4SLC6A2SLC6A4SLC6A3
SCHEMBL8938889 0.71 KMT2A (0.52) GRIN2BGRIN1KDM1AMAOAMAOB
SCHEMBL177865 0.70 TAAR1 (0.61) MAOB
SCHEMBL1144004 0.69 PDE1B (0.47) CYP19A1GID4KDM1AMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0877730-A1 ARYL ACRYLICS FOR USE AS FUNGICIDE MONSANTO COMPANY (US) 1998-11-18 EP disclosed
WO-1997016413-A9 ARYL ACRYLICS FOR USE AS FUNGICIDE 1997-08-14 WO disclosed
WO-1997016413-A1 ARYL ACRYLICS FOR USE AS FUNGICIDE MONSANTO COMPANY (US) 1997-05-09 WO disclosed