Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527896 | 0.80 | CHRNB2 (0.42) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 | |
| SCHEMBL9843049 | 0.78 | TBXAS1 (0.47) | TBXAS1CHRNB2CHRNA4MAPTMAPK1 | |
| SCHEMBL9843054 | 0.78 | TBXAS1 (0.47) | TBXAS1CHRNB2CHRNA4MAPTMAPK1 | |
| SCHEMBL9734003 | 0.71 | TBXAS1 (0.48) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 | |
| SCHEMBL9733996 | 0.71 | TBXAS1 (0.48) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 | |
| SCHEMBL9733100 | 0.70 | TBXAS1 (0.41) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 | |
| SCHEMBL9733096 | 0.70 | TBXAS1 (0.41) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 | |
| SCHEMBL9733052 | 0.70 | TBXAS1 (0.47) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 | |
| SCHEMBL9732792 | 0.70 | TBXAS1 (0.47) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 | |
| SCHEMBL8668533 | 0.69 | CHRNB2 (0.41) | TBXAS1CHRNB2CHRNA4CYP1A2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849766-A | Carbamoyl substituted heterocycles | ELI LILLY AND COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| US-5849922-A | Preparation of substituted alkenoic acids | ELI LILLY AND COMPANY (US) | 1998-12-15 | — | — | US | disclosed |