SCHEMBL8528893

SCHEMBL8528893

Oc1cccc(OC2Cc3ccccc3C2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 1/20 0.49
OPRK1 P41145 1/20 0.49
KCNH2 Q12809 1/20 0.49
IDO1 P14902 2/20 0.42
CHRM3 P20309 5/20 0.41
CHRM2 P08172 1/20 0.41
CHRM4 P08173 1/20 0.41
CHRM5 P08912 1/20 0.41
CHRM1 P11229 1/20 0.41
CHRNB4 P30926 3/20 0.41
CHRNA3 P32297 3/20 0.41
CYP3A4 P08684 2/20 0.41
POLB P06746 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
FFAR1 O14842 1/20 0.38
CA12 O43570 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CA2 P00918 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8527419 0.89 OPRK1 (0.47) OPRM1OPRK1KCNH2IDO1CHRM3
SCHEMBL16902847 0.81 OPRM1 (0.54) OPRM1OPRK1KCNH2CHRM3CHRM2
SCHEMBL9986991 0.81 OPRM1 (0.54) OPRM1OPRK1KCNH2CHRM3CHRM2
SCHEMBL23866998 0.80 HSD17B1 (0.45) OPRM1OPRK1KCNH2CYP3A4
SCHEMBL8528204 0.79 IDO1 (0.47) IDO1MEN1KMT2AFFAR1LMNA
SCHEMBL2385609 0.78 POLB (0.54) OPRM1OPRK1KCNH2CHRM3CHRNB4
SCHEMBL6063449 0.78 OPRM1 (0.51) OPRM1OPRK1KCNH2CHRM3CHRM2
SCHEMBL2387108 0.76 POLB (0.57) OPRM1OPRK1KCNH2CHRM3CHRNB4
SCHEMBL30447835 0.76 SLC6A4 (0.51) OPRM1OPRK1KCNH2CHRM3CHRM2
Water SCHEMBL27641336 0.76 POLB (0.53) OPRM1OPRK1KCNH2CHRM3CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0877730-A1 ARYL ACRYLICS FOR USE AS FUNGICIDE MONSANTO COMPANY (US) 1998-11-18 EP disclosed
US-5739140-A AGRICULTURAL FUNGICIDES MONSANTO COMPANY (US) 1998-04-14 US disclosed
WO-1997016413-A9 ARYL ACRYLICS FOR USE AS FUNGICIDE 1997-08-14 WO disclosed
WO-1997016413-A1 ARYL ACRYLICS FOR USE AS FUNGICIDE MONSANTO COMPANY (US) 1997-05-09 WO disclosed