SCHEMBL8529802

SCHEMBL8529802

O=C(Cl)c1ccccc1Sc1ccc(C(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.48
SLC6A4 P31645 2/20 0.48
SLC6A3 Q01959 1/20 0.48
SIRT1 Q96EB6 1/20 0.46
HTR1A P08908 1/20 0.44
HTR3A P46098 1/20 0.44
MAPT P10636 2/20 0.44
ALDH1A1 P00352 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
DHFR P00374 1/20 0.41
ALOX15 P16050 1/20 0.41
NPC1 O15118 1/20 0.40
CRHBP P24387 1/20 0.40
RAB9A P51151 1/20 0.40
CRHR2 Q13324 1/20 0.40
PTGS1 P23219 1/20 0.39
ICAM1 P05362 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8609339 0.84 SLC6A2 (0.51) SLC6A2SLC6A4SLC6A3SIRT1MAPT
SCHEMBL28437694 0.82 SLC6A2 (0.49) SLC6A2SLC6A4SLC6A3SIRT1HTR1A
SCHEMBL11476180 0.81 SIRT1 (0.67) SIRT1MAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL8533425 0.81 ICAM1 (0.39) SLC6A2SLC6A4SLC6A3MAPTALDH1A1
SCHEMBL8530512 0.81 SLC6A4 (0.55) SLC6A2SLC6A4SLC6A3SIRT1HTR1A
SCHEMBL8533398 0.79 SIRT1 (0.50) SLC6A2SLC6A4SLC6A3SIRT1MAPT
SCHEMBL8534490 0.78 LMNA (0.45) SIRT1MAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL9815789 0.77 ALDH1A1 (0.52) SLC6A2SLC6A4SLC6A3SIRT1MAPT
SCHEMBL8533523 0.75 ALDH1A1 (0.49) SIRT1MAPTALDH1A1LMNAALOX15
SCHEMBL13240454 0.74 LMNA (0.62) SIRT1MAPTALDH1A1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0859757-A1 DERIVATES OF N,N-DIMETHYL-2-(ARYLTHIO)BENZYLAMINE, THEIR SALTS, METHODS OF PREPARATION AND THEIR USE IN PHARMACEUTICAL MEDICAMENTS Farmak A.S. (CZ) 1998-08-26 EP disclosed
WO-1997017325-A1 DERIVATES OF N,N-DIMETHYL-2-(ARYLTHIO)BENZYLAMINE, THEIR SALTS, METHODS OF PREPARATION AND THEIR USE IN PHARMACEUTICAL MEDICAMENTS FARMAK A.S. (CZ) 1997-05-15 WO disclosed