SCHEMBL8530361

SCHEMBL8530361

CC(C)(C)NS(=O)(=O)Nc1ccc(C#N)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
SLC22A12 Q96S37 1/20 0.49
KDM1A O60341 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
HTT P42858 1/20 0.46
ALDH1A1 P00352 3/20 0.44
MAPT P10636 1/20 0.44
CYP19A1 P11511 2/20 0.42
PGR P06401 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
MAPK1 P28482 1/20 0.41
BRD4 O60885 1/20 0.40
IDO1 P14902 2/20 0.40
CA12 O43570 1/20 0.40
CA9 Q16790 1/20 0.40
BRD1 O95696 1/20 0.39
BRPF1 P55201 1/20 0.39
BRPF3 Q9ULD4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13141234 0.77 ALDH1A1 (0.51) CA1CA2SMN1; SMN2HTTALDH1A1
SCHEMBL3366734 0.76 CA1 (0.66) CA1CA2SLC22A12KDM1ASMN1; SMN2
SCHEMBL4959361 0.76 CA1 (0.66) CA1CA2SLC22A12KDM1ASMN1; SMN2
SCHEMBL4491328 0.76 KEAP1 (0.54) CA1CA2SMN1; SMN2ALDH1A1MAPT
SCHEMBL15471145 0.75 CYP19A1 (0.57) CA1CA2KDM1ASMN1; SMN2ALDH1A1
SCHEMBL7338377 0.74 LMNA (0.45) CA1CA2SMN1; SMN2ALDH1A1MAPT
SCHEMBL7357115 0.74 UQCRB (0.46) SMN1; SMN2ALDH1A1MAPTPGRCYP3A4
SCHEMBL28549758 0.73 CA1 (0.61) CA1CA2SLC22A12KDM1ASMN1; SMN2
SCHEMBL11676103 0.72 MAPT (0.55) CA1CA2SMN1; SMN2ALDH1A1MAPT
SCHEMBL1646278 0.72 CA1 (1.00) CA1CA2SLC22A12KDM1ACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5807875-A OBESITY THERAPY DR. KARL THOMAE GMBH (DE) 1998-09-15 US disclosed
US-5616620-A HYPOTENSIVE AGENTS KARL THOMAE GMBH (DE) 1997-04-01 US disclosed