Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533910 | 0.82 | TSHR (0.56) | TACR1LMNATSHRRAB9AALDH1A1 | |
| SCHEMBL8530555 | 0.80 | TACR1 (0.46) | TACR1ALDH1A1MAPTHPGD | |
| SCHEMBL4205532 | 0.78 | ATM (0.45) | NOTUMCA12CA9TACR1LMNA | |
| SCHEMBL4201299 | 0.75 | ALDH1A1 (0.52) | NOTUMCA12CA9TACR1LMNA | |
| SCHEMBL8540447 | 0.74 | TACR1 (0.42) | NOTUMCA12CA9TACR1LMNA | |
| SCHEMBL24240345 | 0.74 | LMNA (0.62) | NOTUMCA12CA9LMNATSHR | |
| SCHEMBL9435026 | 0.74 | MAPT (0.50) | LMNATSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4209233 | 0.74 | LMNA (0.59) | LMNATSHRRAB9AALDH1A1HTT | |
| SCHEMBL4213757 | 0.73 | ALDH1A1 (0.64) | NOTUMLMNATSHRRAB9AALDH1A1 | |
| SCHEMBL15786417 | 0.72 | KMT2A (0.55) | LMNAGAATSHRRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843966-A | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| US-5703240-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-12-30 | — | — | US | disclosed |