Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8885445 | 0.87 | KDM4E (0.43) | LMNAKDM4EKISS1R | |
| Trolamine SCHEMBL8530734 | 0.83 | LMNA (0.33) | MEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL12466254 | 0.82 | MEN1 (0.53) | MEN1LMNAKMT2A | |
| SCHEMBL1868586 | 0.76 | — | — | |
| SCHEMBL337338 | 0.76 | — | — | |
| SCHEMBL4868603 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL3193718 | 0.73 | — | — | |
| Tromethamine SCHEMBL466446 | 0.71 | LMNA (0.62) | MEN1LMNAKMT2A | |
| Meglumine SCHEMBL4685727 | 0.70 | KDM4E (0.73) | MEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL1155666 | 0.69 | MEN1 (0.53) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5844103-A | Anionic glycasuccinamide sufactants and a process for their manufacture | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| US-5786468-A | NONIONIC SURFACTANTS DERIVED FROM CARBOHYDRATES FOR SHAMPOO, DEODORANTS OR CLEANING COMPOUNDS | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1998-07-28 | — | — | US | disclosed |