Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL8885448 | 0.88 | KDM4E (0.40) | LMNAKDM4EALDH1A1 | |
| Tromethamine SCHEMBL8530728 | 0.83 | MEN1 (0.36) | LMNAMEN1KMT2AKDM4E | |
| Trolamine SCHEMBL460514 | 0.75 | MEN1 (0.59) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| Trolamine SCHEMBL10479188 | 0.75 | MEN1 (0.59) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| Trolamine SCHEMBL11046229 | 0.73 | MEN1 (0.56) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL337338 | 0.73 | — | — | |
| SCHEMBL4868603 | 0.73 | — | — | |
| SCHEMBL1868586 | 0.73 | — | — | |
| Trolamine SCHEMBL5144735 | 0.71 | MEN1 (0.53) | LMNAMEN1KMT2A | |
| Trolamine SCHEMBL28287362 | 0.71 | MEN1 (0.34) | LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5844103-A | Anionic glycasuccinamide sufactants and a process for their manufacture | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| US-5786468-A | NONIONIC SURFACTANTS DERIVED FROM CARBOHYDRATES FOR SHAMPOO, DEODORANTS OR CLEANING COMPOUNDS | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1998-07-28 | — | — | US | disclosed |