Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 5/20 | 0.43 |
| ▸ | TCF4 | P15884 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | CTH | P32929 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531494 | 0.93 | DNMT3B (0.53) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| SCHEMBL1450338 | 0.66 | MAOA (0.46) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| Nanaomycin SCHEMBL20473784 | 0.66 | HSP90AA1 (1.00) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| Nanaomycin SCHEMBL30778402 | 0.66 | HSP90AA1 (1.00) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| Nanaomycin SCHEMBL30861963 | 0.66 | HSP90AA1 (1.00) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| Nanaomycin SCHEMBL18567076 | 0.66 | HSP90AA1 (1.00) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| Nanafrocin SCHEMBL2111571 | 0.66 | HSP90AA1 (1.00) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| SCHEMBL8899879 | 0.66 | AKT1 (0.33) | DNMT3BHSP90AA1PAX8AKT1 | |
| SCHEMBL30193239 | 0.65 | DNMT3B (0.82) | DNMT3BHSP90AA1PAX8TDP2AKT1 | |
| SCHEMBL396216 | 0.64 | TDP2 (1.00) | DNMT3BHSP90AA1PAX8TDP2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5606037-A | Processes antineoplastic heteronaphthoquinones | BIOCHEM PHARMA INC. (CA) | 1997-02-25 | — | — | US | claimed |
| US-5736523-A | ADMINISTERING TO THE MAMMAL SUFFERING FROM CANCER | BIOCHEM PHARMA INC. (CA) | 1998-04-07 | — | — | US | disclosed |
| US-5606037-A | Processes antineoplastic heteronaphthoquinones | BIOCHEM PHARMA INC. (CA) | 1997-02-25 | — | — | US | disclosed |
| EP-0659190-A1 | ANTINEOPLASTIC HETERONAPHTHOQUINONES | BIOCHEM PHARMA INC (CA) | 1995-06-28 | — | — | EP | disclosed |
| WO-1994011382-A1 | ANTINEOPLASTIC HETERONAPHTHOQUINONES | BIOCHEM PHARMA INC. (CA) | 1994-05-26 | — | — | WO | disclosed |