SCHEMBL8531702

SCHEMBL8531702

CCC(=O)c1ccn(Cc2ccc(OC(F)(F)F)cc2)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 5/20 0.55
CACNA1G O43497 3/20 0.55
CACNA1I Q9P0X4 3/20 0.55
ALDH1A1 P00352 2/20 0.48
TSHR P16473 1/20 0.45
KMT2A Q03164 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
HRH3 Q9Y5N1 2/20 0.42
AADAT Q8N5Z0 1/20 0.42
KLKB1 P03952 2/20 0.41
TP53 P04637 1/20 0.40
MAPT P10636 1/20 0.40
PPARD Q03181 1/20 0.40
PPARA Q07869 1/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8534390 0.77 KLKB1 (0.55) CACNA1HCACNA1GCACNA1IALDH1A1TSHR
SCHEMBL17316720 0.74 CACNA1G (0.52) CACNA1HCACNA1GCACNA1IALDH1A1TSHR
SCHEMBL8641487 0.74 CACNA1H (0.52) CACNA1HCACNA1GCACNA1IALDH1A1TSHR
SCHEMBL24310644 0.72 HDAC1 (0.45) CACNA1HCACNA1GCACNA1IALDH1A1TSHR
SCHEMBL1906943 0.72 KMT2A (0.60) CACNA1HCACNA1GCACNA1IALDH1A1KMT2A
SCHEMBL17316771 0.72 CACNA1G (0.50) CACNA1HCACNA1GCACNA1IALDH1A1TSHR
SCHEMBL31598793 0.72 CACNA1G (0.50) CACNA1HCACNA1GCACNA1I
SCHEMBL19902346 0.72 ALDH1A1 (0.40) ALDH1A1TSHRKMT2ACYP1A2CYP2D6
SCHEMBL17316589 0.72 CACNA1I (1.00) CACNA1HCACNA1GCACNA1I
SCHEMBL28111821 0.71 ALDH1A1 (0.54) ALDH1A1TSHRKMT2ACYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012069856-A1 ANTIMALARIAL COMPOUNDS LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) 2012-05-31 WO disclosed
WO-2012069856-A1 ANTIMALARIAL COMPOUNDS LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) 2012-05-31 WO disclosed