SCHEMBL8532151

SCHEMBL8532151

COc1nc(C)nc(NC(=O)O)n1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.49
MAPT P10636 2/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CYP1A2 P05177 1/20 0.38
LMNA P02545 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 1/20 0.37
KMT2A Q03164 2/20 0.36
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
RECQL P46063 1/20 0.35
POLB P06746 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7031311 0.90 MAPT (0.46) GAAMAPTHTTNPSR1CYP1A2
SCHEMBL9480478 0.87 GAA (0.47) GAAMAPTHTTNPSR1CYP1A2
SCHEMBL4286264 0.85 GAA (0.46) GAAMAPTHTTNPSR1CYP1A2
SCHEMBL19956431 0.84 GAA (0.45) GAAMAPTHTTNPSR1CYP1A2
SCHEMBL7932221 0.81 GAA (0.46) GAAMAPTHTTNPSR1CYP1A2
SCHEMBL8678377 0.80 GAA (0.42) GAAMAPTHTTNPSR1CYP1A2
SCHEMBL24652648 0.79 GAA (0.51) GAAMAPTHTTNPSR1CYP1A2
SCHEMBL10858218 0.79 GAA (0.41) GAAKMT2A
SCHEMBL2893620 0.78 ALDH1A1 (0.49) GAAMAPTHTTCYP1A2LMNA
SCHEMBL6906036 0.77 GAA (0.40) GAAMAPTHTTNPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10059676-B2 Process for preparing a novel crystalline form of iodosulfuron-methyl-sodium and use of the same ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) 2018-08-28 US disclosed
US-9700053-B2 Synergistic herbicidal composition and use thereof ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) 2017-07-11 US disclosed
US-20170121294-A1 PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF IODOSULFURON-METHYL-SODIUM AND USE OF THE SAME ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED (HK) 2017-05-04 US disclosed
US-20170118987-A1 SYNERGISTIC HERBICIDAL COMPOSITION AND USE THEREOF ROTAM AGROCHEM INTERNATIONAL CO., LTD (CN) 2017-05-04 US disclosed
EP-0574418-B1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-11-11 EP disclosed
US-5723410-A PLANT GROWTH REGULATORS AND HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1998-03-03 US disclosed
US-5688745-A Arylsulfonylureas and their use as herbicides and growth regulators HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-18 US disclosed
EP-0546082-B1 HERBICIDAL PYRROLESULFONYLUREAS DU PONT (US) 1996-12-18 EP disclosed
US-5585328-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-12-17 US disclosed
US-5583231-A HERBICIDE ISHIHARA SANGYO KAISHA, LTD. (JP) 1996-12-10 US disclosed
US-4746358-A PLANT GROWTH REGULATORS, HERBICIDES; N-TRIAZINYL-AMINOCARBONYL -1,4-BENZODIOXANESULFONAMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-24 US disclosed
EP-0083975-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-11-19 EP disclosed
US-4699649-A Herbicidal heterocyclicbenzylsulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-10-13 US disclosed
US-4695311-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-09-22 US disclosed
US-4659368-A HERBICIDES; PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-04-21 US disclosed
US-4606755-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-08-19 US disclosed
US-4511392-A N--/PYRIMIDIN-2-YLAMINOCARBENYL/-HETERO-SUBSTITUETED BENZENSESULFO E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-16 US disclosed
US-4502882-A HERBICIDES, PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-03-05 US disclosed
EP-0083975-A2 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-07-20 EP disclosed
EP-0082681-A2 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-06-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170121294-A1 PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF IODOSULFURON-METHYL-SODIUM AND USE OF THE SAME SCLY, STS, MPST GAA 3258/4885MAPT 2387/4885HTT 2376/4885
US-10059676-B2 Process for preparing a novel crystalline form of iodosulfuron-methyl-sodium and use of the same SCLY, STS, MPST GAA 3258/4885MAPT 2387/4885HTT 2376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.