Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533064 | 0.88 | PTGS1 (0.40) | PTGS2SMN1; SMN2MCL1PRKAB2PRKAG1 | |
| SCHEMBL8529462 | 0.76 | FOLH1 (0.40) | PTGS2SMN1; SMN2 | |
| SCHEMBL8533224 | 0.73 | SLC9A1 (0.49) | PTGS2SLC9A1 | |
| SCHEMBL8529538 | 0.70 | PTGS2 (0.41) | PTGS2AKR1C2AKR1C1AKR1C3KMT2A | |
| SCHEMBL9419340 | 0.68 | SMN1; SMN2 (0.47) | PTGS2SMN1; SMN2MCL1PRKAB2PRKAG1 | |
| SCHEMBL8529625 | 0.67 | PTGS2 (0.38) | PTGS2SMN1; SMN2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL27346968 | 0.66 | PTGS2 (0.35) | PTGS2SMN1; SMN2KMT2A | |
| SCHEMBL6495696 | 0.66 | HSD17B10 (0.58) | SMN1; SMN2MCL1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL6498971 | 0.66 | HDAC7 (0.57) | SMN1; SMN2MCL1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30832923 | 0.65 | MCL1 (0.58) | SMN1; SMN2MCL1PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699660-B1 | Arylbenzoylguanidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5807896-A | Arylbenzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 1998-09-15 | — | — | US | disclosed |
| EP-0699660-A2 | Arylbenzoylguanidines | MERCK PATENT GmbH (DE) | 1996-03-06 | — | — | EP | disclosed |