Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | FABP2 | P12104 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27526742 | 0.85 | PTGS2 (0.37) | PTGS2PTGS1MEN1KMT2AFABP2 | |
| SCHEMBL8534063 | 0.84 | CA1 (0.42) | PTGS2PTGS1MEN1KMT2AHNF4A | |
| SCHEMBL8534938 | 0.82 | SLC9A1 (0.44) | — | |
| SCHEMBL8529625 | 0.81 | PTGS2 (0.38) | PTGS2PTGS1MEN1KMT2AFABP2 | |
| SCHEMBL8529462 | 0.79 | FOLH1 (0.40) | PTGS2HNF4AMAPTFABP4FABP5 | |
| SCHEMBL5728666 | 0.78 | HNF4A (0.48) | PTGS2PTGS1MEN1KMT2AFABP2 | |
| SCHEMBL8533251 | 0.78 | KDM4E (0.47) | PTGS2MEN1KMT2AHNF4ALMNA | |
| SCHEMBL7411266 | 0.78 | PTGS2 (0.43) | PTGS2PTGS1MAPTHPGDACLY | |
| SCHEMBL28755647 | 0.77 | DHODH (0.47) | PTGS2PTGS1MEN1KMT2AFABP2 | |
| SCHEMBL7235842 | 0.77 | LMNA (0.47) | AKR1C2AKR1C1LMNAACLYACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1055919-C | Arylbenzoylguanidin | MERCK PATENT GMBH (DE) | 2000-08-30 | — | — | CN | disclosed |
| EP-0699660-B1 | Arylbenzoylguanidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5807896-A | Arylbenzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 1998-09-15 | — | — | US | disclosed |
| EP-0699660-A2 | Arylbenzoylguanidines | MERCK PATENT GmbH (DE) | 1996-03-06 | — | — | EP | disclosed |