Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533248 | 0.87 | FOLH1 (0.39) | FOLH1HNF4AMAPTPKMMAPK1 | |
| SCHEMBL27346968 | 0.85 | PTGS2 (0.35) | FOLH1PTGS2SMN1; SMN2PTGDR2 | |
| SCHEMBL8529748 | 0.83 | SLC9A1 (0.43) | — | |
| SCHEMBL8529538 | 0.79 | PTGS2 (0.41) | FOLH1PTGS2HNF4AMAPTPTPN1 | |
| SCHEMBL28379211 | 0.78 | HNF4A (0.46) | FOLH1HNF4AMAPTPKMMAPK1 | |
| SCHEMBL8533097 | 0.76 | PTGS2 (0.38) | PTGS2SMN1; SMN2 | |
| SCHEMBL8533251 | 0.75 | KDM4E (0.47) | FOLH1PTGS2HNF4ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8529625 | 0.75 | PTGS2 (0.38) | FOLH1PTGS2HNF4AMAPTMAPK1 | |
| SCHEMBL29492888 | 0.75 | FOLH1 (0.44) | FOLH1HNF4AMAPTPKMMAPK1 | |
| SCHEMBL10984209 | 0.74 | HNF4A (0.58) | FOLH1HNF4AMAPTSMN1; SMN2FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1055919-C | Arylbenzoylguanidin | MERCK PATENT GMBH (DE) | 2000-08-30 | — | — | CN | disclosed |
| EP-0699660-B1 | Arylbenzoylguanidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5807896-A | Arylbenzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTING (DE) | 1998-09-15 | — | — | US | disclosed |
| EP-0699660-A2 | Arylbenzoylguanidines | MERCK PATENT GmbH (DE) | 1996-03-06 | — | — | EP | disclosed |
| CN-1117962-A | Arylbenzoylguanidin | MERCK PATENT GMBH (DE) | 1996-03-06 | — | — | CN | disclosed |