Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534988 | 0.79 | CYP11B1 (0.41) | CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL8531874 | 0.75 | DGAT1 (0.36) | CYP26A1CYP24A1 | |
| SCHEMBL8534684 | 0.73 | DGAT1 (0.50) | CYP26A1CYP24A1 | |
| SCHEMBL20804911 | 0.67 | DPP4 (0.47) | ROCK2ROCK1POLBDPP4DPP8 | |
| SCHEMBL13077117 | 0.67 | DPP4 (0.47) | ROCK2ROCK1POLBDPP4DPP8 | |
| SCHEMBL19321965 | 0.67 | HTR7 (0.57) | ROCK2PLATHTR7POLB | |
| SCHEMBL13662567 | 0.67 | ROCK2 (0.46) | ROCK2ROCK1PLATPOLBDPP4 | |
| SCHEMBL10272737 | 0.67 | ROCK2 (0.46) | ROCK2ROCK1PLATPOLBDPP4 | |
| SCHEMBL13189047 | 0.66 | DPP4 (0.49) | ROCK2ROCK1POLBDPP4DPP8 | |
| SCHEMBL4023639 | 0.65 | POLB (0.46) | ROCK2ROCK1PLATPOLBDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847159-A | 1- ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0825180-A1 | 1-OMEGA-(3,4-DIHYDRO-2-NAPHTHALENYL)ALKYL] CYCLIC AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |