Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31486076 | 0.79 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2EGLN2PDE4A | |
| SCHEMBL5248703 | 0.78 | CSNK1A1 (0.44) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL8536429 | 0.75 | VCAM1 (0.50) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL8539349 | 0.75 | HCRTR1 (0.40) | CYP19A1CYP11B1CYP11B2EGLN2PDE4A | |
| SCHEMBL21657456 | 0.75 | ADRA2A (0.49) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL8537063 | 0.75 | NR4A2 (0.43) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL22636621 | 0.75 | CLK4 (0.51) | EGLN2MAP3K14KDM4EALDH1A1GAA | |
| SCHEMBL378124 | 0.74 | NISCH (0.58) | CYP19A1CYP11B2PDE4APDE4BPDE4C | |
| SCHEMBL8540558 | 0.74 | VCAM1 (0.46) | CYP19A1CYP11B1CYP11B2PDE4APDE4B | |
| SCHEMBL8539601 | 0.74 | CYP19A1 (0.41) | CYP19A1CYP11B1CYP11B2EGLN2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |