SCHEMBL8539601

SCHEMBL8539601

CSCc1cc(C#N)ccc1-c1ncc[nH]1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.41
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
HCRTR1 O43613 1/20 0.39
HCRTR2 O43614 1/20 0.39
PDE4A P27815 1/20 0.36
PDE4B Q07343 1/20 0.36
PDE4C Q08493 1/20 0.36
PDE4D Q08499 1/20 0.36
EGLN2 Q96KS0 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
ADORA3 P0DMS8 2/20 0.34
ADORA2A P29274 2/20 0.34
ADORA1 P30542 2/20 0.34
NISCH Q9Y2I1 2/20 0.33
METAP2 P50579 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8541136 0.82 CYP19A1 (0.39) CYP19A1CYP11B1CYP11B2HCRTR1HCRTR2
SCHEMBL8540790 0.80 NISCH (0.37) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8539349 0.79 HCRTR1 (0.40) CYP19A1CYP11B1CYP11B2HCRTR1HCRTR2
SCHEMBL8540597 0.79 CSNK1A1 (0.36) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8536816 0.79 JAK2 (0.47) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8541400 0.79 MC4R (0.37) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8540730 0.79 MC4R (0.46) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8537087 0.77 CSNK1A1 (0.45) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8539649 0.77 NOS3 (0.47) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8535625 0.76 NISCH (0.49) CYP19A1CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0857171-A2 IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1998-08-12 EP disclosed
WO-1997015555-A2 IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1997-05-01 WO disclosed