Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.33 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.33 |
| ▸ | S100A9 | P06702 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540658 | 0.80 | JAK2 (0.48) | ADRA1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8539601 | 0.79 | CYP19A1 (0.41) | HCRTR1HCRTR2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8540682 | 0.78 | CSNK1A1 (0.47) | CYP19A1ADRA1ACSNK1A1TYRO3DYRK1B | |
| SCHEMBL8541136 | 0.77 | CYP19A1 (0.39) | HCRTR1HCRTR2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8535598 | 0.75 | CYP19A1 (0.46) | HCRTR1HCRTR2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL31486076 | 0.71 | CYP19A1 (0.45) | HCRTR1HCRTR2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8536429 | 0.69 | VCAM1 (0.50) | HCRTR1HCRTR2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8540558 | 0.68 | VCAM1 (0.46) | HCRTR1HCRTR2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8617021 | 0.68 | CSNK1A1 (0.44) | ADRA1ACSNK1A1TYRO3DYRK1BNISCH | |
| SCHEMBL22637167 | 0.67 | MBOAT4 (0.41) | CYP11B1CYP11B2TRPV4HRH4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |