Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538107 | 0.85 | MAPT (0.43) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL5249670 | 0.80 | MAPT (0.56) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL8539529 | 0.80 | GPR35 (0.49) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL31463535 | 0.78 | AMY1A (0.48) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL5747525 | 0.78 | MEN1 (0.46) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL8540776 | 0.78 | AMY1A (0.48) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL8536125 | 0.78 | NPC1 (0.43) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL8536108 | 0.78 | HTT (0.51) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL4055359 | 0.77 | HSD17B10 (0.49) | NPC1MEN1KMT2ARAB9AHSP90AA1 | |
| SCHEMBL9292469 | 0.77 | NPC1 (0.44) | NPC1MEN1KMT2ARAB9AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |