Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.36 |
| ▸ | SORD | Q00796 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515288 | 0.94 | CARM1 (0.39) | DKK1CTSSCTSKPIK3C3KMO | |
| SCHEMBL8515329 | 0.91 | ACHE (0.41) | DKK1CTSSCTSKKMOSORD | |
| SCHEMBL9612650 | 0.89 | CARM1 (0.41) | DKK1CTSSCTSKKMOSORD | |
| SCHEMBL8510840 | 0.85 | KMO (0.43) | DKK1KMOSORDPIK3CA | |
| SCHEMBL8511678 | 0.85 | DKK1 (0.58) | DKK1KMOAAK1SORDPIK3CA | |
| SCHEMBL8515556 | 0.85 | MEN1 (0.40) | DKK1CTSSCTSKKMOSORD | |
| SCHEMBL8512439 | 0.83 | DKK1 (0.56) | DKK1KMOSORDPIK3CA | |
| SCHEMBL8511790 | 0.83 | ROCK2 (0.41) | DKK1KMOPIK3CAACHE | |
| SCHEMBL8514120 | 0.83 | KMO (0.40) | DKK1KMOSORDPIK3CA | |
| SCHEMBL8510713 | 0.83 | KMO (0.39) | DKK1KMOSORDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |