Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541277 | 0.90 | JAK2 (0.44) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL8540790 | 0.84 | NISCH (0.37) | JAK2JAK1TYK2JAK3CASP6 | |
| SCHEMBL8540730 | 0.82 | MC4R (0.46) | JAK2JAK1TYK2JAK3CASP6 | |
| SCHEMBL8541400 | 0.82 | MC4R (0.37) | JAK2JAK1TYK2JAK3CASP6 | |
| SCHEMBL8540597 | 0.82 | CSNK1A1 (0.36) | JAK2JAK1TYK2JAK3CASP6 | |
| SCHEMBL8537087 | 0.80 | CSNK1A1 (0.45) | CASP6CSNK1A1TYRO3DYRK1BNISCH | |
| SCHEMBL8538833 | 0.80 | JAK2 (0.46) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL8539649 | 0.80 | NOS3 (0.47) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL8537559 | 0.79 | MC4R (0.44) | JAK2JAK1TYK2JAK3CASP6 | |
| SCHEMBL8535625 | 0.79 | NISCH (0.49) | JAK2JAK1TYK2JAK3CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |