Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.40 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536671 | 0.90 | NOS3 (0.46) | NOS3NOS1NOS2ADRA2AADRA2C | |
| SCHEMBL8536462 | 0.85 | CYP1A2 (0.44) | NOS3NOS1NOS2ADRA1ACYP1A2 | |
| SCHEMBL8538130 | 0.82 | MAOB (0.43) | CYP3A4KDM4E | |
| SCHEMBL8543161 | 0.82 | SMPD3 (0.46) | NOS3NOS1NOS2ADRA1ACYP1A2 | |
| SCHEMBL8540790 | 0.81 | NISCH (0.37) | NOS3NOS1NOS2ADRA2AADRA1A | |
| SCHEMBL8537031 | 0.81 | ADRA2A (0.39) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL8536816 | 0.80 | JAK2 (0.47) | ADRA1ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8540730 | 0.80 | MC4R (0.46) | ADRA2AADRA2CADRA1ACYP1A2CYP3A4 | |
| SCHEMBL8541400 | 0.80 | MC4R (0.37) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8540597 | 0.80 | CSNK1A1 (0.36) | ADRA1ACYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |