Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541143 | 0.90 | MAPK1 (0.51) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5249670 | 0.83 | MAPT (0.56) | GSK3BRAB9AMAPK1TSHRNPC1 | |
| SCHEMBL8536034 | 0.82 | ESR1 (0.43) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL8540810 | 0.82 | TSHR (0.50) | RAB9ATSHRNPC1MAPTNFKB1 | |
| SCHEMBL5528175 | 0.82 | S100A4 (0.46) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL10680334 | 0.81 | MAPT (0.39) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL1303527 | 0.80 | CSNK1A1 (0.50) | RAB9AMAPTHPGDALDH1A1L3MBTL1 | |
| SCHEMBL8536429 | 0.78 | VCAM1 (0.50) | MAPK1MAPTPDE4BPDE4DVCAM1 | |
| SCHEMBL8536432 | 0.78 | ALDH1A1 (0.48) | GSK3BRAB9AMAPK1NPC1MAPT | |
| SCHEMBL6125034 | 0.78 | MAPK1 (0.63) | RAB9AMAPK1TSHRNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |