Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | PRCP | P42785 | 1/20 | 0.53 |
| ▸ | EBP | Q15125 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19276039 | 0.84 | DRD3 (0.45) | SIGMAR1DRD3DRD2DRD4NFKB1 | |
| SCHEMBL7298696 | 0.84 | DRD2 (0.57) | SIGMAR1DRD3DRD2DRD4NFKB1 | |
| SCHEMBL19275748 | 0.82 | ALDH1A1 (0.49) | — | |
| SCHEMBL19275745 | 0.82 | RIPK1 (0.58) | — | |
| SCHEMBL8541194 | 0.81 | DRD2 (0.59) | DRD2 | |
| SCHEMBL23423397 | 0.80 | CHRNB2 (0.59) | DRD3DRD2DRD4PRCP | |
| SCHEMBL23032150 | 0.80 | CHRNB2 (0.59) | DRD3DRD2DRD4PRCP | |
| SCHEMBL13407277 | 0.80 | CHRNB2 (0.59) | DRD3DRD2DRD4PRCP | |
| SCHEMBL24310054 | 0.80 | CHRNB2 (0.64) | SIGMAR1DRD3DRD2DRD4NFKB1 | |
| SCHEMBL19275752 | 0.79 | THRB (0.56) | DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0671388-B1 | (Pyrrolidinyl)phenyl carbamates and intermediate compounds, processes for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5591856-A | CHEMICAL INTERMEDIATES, TREATMENT OF ALZHEIMER'S DISEASE | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5554750-A | TO RELIEVE MEMORY DYSFUNCTIONS; TREATMENT OF ALZHEMER*S | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0671388-A1 | (Pyrrolidinyl)phenyl carbamates and intermediate compounds, processes for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5405845-A | Administering to relieve memory dysfunction; treatment of Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5338739-A | Memory dysfunction relieving compounds | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-08-16 | — | — | US | disclosed |