Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267209 | 0.89 | MAPT (0.55) | HTTKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL1442018 | 0.86 | NPC1 (0.56) | RAB9ANPC1PKMSMN1; SMN2LMNA | |
| SCHEMBL21480338 | 0.85 | RAB9A (0.59) | RAB9ANPC1PKMSMN1; SMN2LMNA | |
| SCHEMBL11552829 | 0.84 | HTR2A (0.52) | RAB9ANPC1PKMLMNATHRA | |
| SCHEMBL8537570 | 0.84 | THRB (0.48) | RAB9ANPC1PKMHTTTHRA | |
| SCHEMBL8571284 | 0.84 | RAB9A (0.58) | RAB9ANPC1PKMSMN1; SMN2LMNA | |
| SCHEMBL9114685 | 0.84 | NPC1 (0.57) | RAB9ANPC1PKMSMN1; SMN2LMNA | |
| SCHEMBL10788695 | 0.84 | SMN1; SMN2 (0.61) | RAB9ANPC1PKMSMN1; SMN2LMNA | |
| SCHEMBL15076021 | 0.84 | THRA (0.61) | RAB9ANPC1PKMSMN1; SMN2LMNA | |
| SCHEMBL14930210 | 0.84 | PDE4B (0.62) | RAB9ANPC1PKMSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750532-A | TETRAHYDROPYRIMIDINE-2,4-DIONE DERIVATIVES, VIRICIDES, ANTIINFLAMMATORY AGENTS, PAF INHIBITORS | SCHERING CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |