Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070825 | 0.91 | SLC9A1 (0.42) | SLC9A1 | |
| SCHEMBL6932460 | 0.90 | PLAU (0.39) | KMT2ASLC9A1MEN1 | |
| SCHEMBL6938051 | 0.90 | KIF18A (0.44) | KIF18AKMT2ASLC9A1MEN1 | |
| SCHEMBL6937331 | 0.90 | SLC9A1 (0.40) | SLC9A1 | |
| SCHEMBL6932987 | 0.89 | MAPT (0.44) | KIF18ASLC9A1 | |
| SCHEMBL6937615 | 0.88 | HPD (0.37) | SLC9A1 | |
| SCHEMBL6938965 | 0.87 | SLC9A1 (0.39) | SLC9A1POLBF2PRSS1PRSS2 | |
| SCHEMBL6932550 | 0.87 | SLC9A1 (0.51) | KIF18AKMT2ASLC9A1MEN1 | |
| SCHEMBL27531430 | 0.87 | KIF18A (0.46) | KIF18AKMT2AMEN1POLBABCC9 | |
| SCHEMBL6937336 | 0.86 | ALDH1A1 (0.44) | KMT2ASLC9A1MEN1POLBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |