Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.77 |
| ▸ | MAPT | P10636 | 8/20 | 0.77 |
| ▸ | MEN1 | O00255 | 7/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.65 |
| ▸ | EGFR | P00533 | 5/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.57 |
| ▸ | BLM | P54132 | 3/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17466932 | 0.88 | MAPT (1.00) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL17466936 | 0.81 | MAPT (0.85) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL1238796 | 0.79 | MEN1 (1.00) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL11350306 | 0.78 | ALDH1A1 (0.62) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL26552234 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL20824922 | 0.78 | KMT2A (0.80) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL3369467 | 0.77 | KMT2A (0.77) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL987696 | 0.77 | MAPT (0.77) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL21887201 | 0.77 | MAPT (0.77) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6824611 | 0.77 | KMT2A (0.77) | ALDH1A1KMT2AMAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113717076-B | Preparation method for obtaining methane functional product based on iron/light combined catalysis | 大连理工大学 | 2022-08-02 | — | — | CN | claimed |
| CN-118287150-A | Method for efficiently catalyzing Knoevenagel condensation reaction by porphyrin and quaternary ammonium salt synergistic catalytic system | 沈阳药科大学 | 2024-07-05 | — | — | CN | disclosed |
| CN-116239573-B | Preparation method and application of metal organic quaternary cyclic compound | 大连理工大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-117683009-A | Polysubstituted 4H-pyran derivative and preparation method thereof | 郑州铁路职业技术学院 | 2024-03-12 | — | — | CN | disclosed |
| CN-117623983-A | Method for constructing cyclopentene skeleton by directly cyclizing allyl alcohol | 南京工业大学 | 2024-03-01 | — | — | CN | disclosed |
| CN-117551025-A | Preparation method of 4, 4-dicyano-2-alkyl-pyrrolidine-2-carboxylic ester derivative | 华北水利水电大学 | 2024-02-13 | — | — | CN | disclosed |
| CN-116535368-A | Dicyanomethane compound and synthesis method and application thereof | 浙江理工大学嵊州创新研究院有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-116239573-A | Preparation method and application of metal organic quaternary cyclic compound | 大连理工大学 | 2023-06-09 | — | — | CN | disclosed |
| CN-113135856-B | 3-trifluoromethyl-5-cyanopyrazole compounds and preparation method thereof | 天津大学 | 2022-10-11 | — | — | CN | disclosed |
| CN-113717076-B | Preparation method for obtaining methane functional product based on iron/light combined catalysis | 大连理工大学 | 2022-08-02 | — | — | CN | disclosed |
| US-9410035-B2 | Modified heterophasic polyolefin composition | MILLIKEN & COMPANY (US) | 2016-08-09 | — | — | US | disclosed |
| US-20160024289-A1 | MODIFIED HETEROPHASIC POLYOLEFIN COMPOSITION | MILLIKEN & COMPANY | 2016-01-28 | — | — | US | disclosed |
| EP-1476435-B1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| US-7022718-B2 | Pyridine and pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20050143405-A1 | Pyridine and pyrimidine derivatives | BOEHRINGER MARKUS (CH) | 2005-06-30 | — | — | US | disclosed |
| US-6867205-B2 | Pyridine and pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1476435-A1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068757-A9 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-10-07 | — | — | WO | disclosed |
| US-20030216382-A1 | Pyridine and pyrimidine derivatives | HOFFMAN-LA ROCHE INC. | 2003-11-20 | — | — | US | disclosed |
| WO-2003068757-A1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216382-A1 | Pyridine and pyrimidine derivatives | DPP4, GPR119, G6PC1 | ALDH1A1 152/4885KMT2A 3893/4885MAPT 4559/4885 |
| US-20050143405-A1 | Pyridine and pyrimidine derivatives | DPP4, GPR119, PDXK | ALDH1A1 330/4885KMT2A 3650/4885MAPT 4458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.