Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539453 | 1.00 | P2RX7 (0.48) | P2RX7CASP1LMNACTRB1CASP3 | |
| SCHEMBL3070245 | 0.83 | P2RX7 (0.48) | P2RX7LMNACTRB1CA1CA2 | |
| SCHEMBL9476901 | 0.83 | CTRB1 (0.56) | P2RX7LMNACTRB1CA1CA2 | |
| SCHEMBL7990292 | 0.81 | LMNA (0.48) | P2RX7LMNACTRB1CA1CA2 | |
| SCHEMBL3652008 | 0.80 | P2RX7 (0.51) | P2RX7LMNACA1CA2MAPT | |
| SCHEMBL3652010 | 0.80 | P2RX7 (0.51) | P2RX7LMNACA1CA2MAPT | |
| SCHEMBL22552853 | 0.80 | P2RX7 (0.51) | P2RX7LMNACA1CA2MAPT | |
| SCHEMBL6924285 | 0.80 | LMNA (0.59) | P2RX7LMNACA1CA2MAPT | |
| SCHEMBL7990303 | 0.79 | P2RX7 (0.47) | P2RX7LMNACTRB1CA1CA2 | |
| SCHEMBL3957822 | 0.79 | P2RX7 (0.54) | P2RX7CASP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0565396-B1 | 1-[2-(arylsulfonylamino)-1-oxoethyl]piperidine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1998-01-07 | — | — | EP | disclosed |
| EP-0579277-A1 | Imidazole derivatives, their preparation and their use as synthetic intermediates | SYNTHELABO (FR) | 1994-01-19 | — | — | EP | disclosed |