SCHEMBL8540154

SCHEMBL8540154

C[C@H](NC(=O)CNC(=O)[C@@H](N)CCCCN)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ GNAI3 P08754 1/20 0.50
▸ GNAO1 P09471 1/20 0.50
▸ GNAI1 P63096 1/20 0.50
▸ GSR P00390 1/20 0.49
▸ TERT O14746 5/20 0.48
▸ MMP2 P08253 1/20 0.44
▸ DPP7 Q9UHL4 4/20 0.44
▸ DPP8 Q6V1X1 2/20 0.44
▸ DPP9 Q86TI2 2/20 0.44
▸ TLR2 O60603 2/20 0.40
▸ FAAH O00519 1/20 0.40
▸ RRM1 P23921 1/20 0.39
▸ DPP4 P27487 1/20 0.39
▸ OPRM1 P35372 1/20 0.38
▸ OPRD1 P41143 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8540142 1.00 GNAI3 (0.50) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL16615963 0.96 GNAI3 (0.47) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL3896673 0.90 GNAI3 (0.42) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL5697801 0.90 GNAI3 (0.42) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL30531774 0.90 GSR (0.42) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL30880423 0.88 GNAI3 (0.45) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL847121 0.87 GNAI3 (0.44) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL847122 0.87 GNAI3 (0.44) GNAI3GNAO1GNAI1GSRTERT
SCHEMBL7781619 0.85 GSR (0.58) GNAI3GNAO1GNAI1GSRMMP2
SCHEMBL1641744 0.85 GSR (0.58) GNAI3GNAO1GNAI1GSRMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12128110-B2 Transglutaminase conjugation method and linker PAUL SCHERRER INSTITUT (CH) 2024-10-29 — — US claimed
US-5750555-A NERVOUS SYSTEM DISORDERS; SKIN DISORDERS; IMMUNOLOGY GOEDECKE AKTIENGESELLSCHAFT (DE) 1998-05-12 — — US claimed
EP-0674632-A1 AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS GÖDECKE AKTIENGESELLSCHAFT (DE) 1995-10-04 — — EP claimed
WO-1994014798-A1 AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS Gödecke Aktiengesellschaft (DE) 1994-07-07 — — WO claimed
EP-3897693-B1 SYNTHETIC AND RECOMBINANT COLLAGEN PEPTIDES HAVING BIOLOGICAL ACTIVITY GELITA AG (DE) 2025-08-06 — — EP disclosed
US-20250161479-A1 TRANSGLUTAMINASE CONJUGATION METHOD AND LINKER PAUL SCHERRER INSTITUT (CH) 2025-05-22 — — US disclosed
CN-120005928-A Dynamic regulation and control system, strain, construction method of strain and application of strain in microbial fuel cell 天津科技大学 2025-05-16 — — CN disclosed
US-12128110-B2 Transglutaminase conjugation method and linker PAUL SCHERRER INSTITUT (CH) 2024-10-29 — — US disclosed
US-20240350656-A1 TRANSGLUTAMINASE CONJUGATION METHOD AND LINKER PAUL SCHERRER INSTITUT (CH) 2024-10-24 — — US disclosed
US-5750555-A NERVOUS SYSTEM DISORDERS; SKIN DISORDERS; IMMUNOLOGY GOEDECKE AKTIENGESELLSCHAFT (DE) 1998-05-12 — — US disclosed
EP-0674632-A1 AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS GÖDECKE AKTIENGESELLSCHAFT (DE) 1995-10-04 — — EP disclosed
WO-1994014798-A1 AMINOACID DERIVATIVES OF HETEROCYCLES AS PROTEIN KINASE C INHIBITORS Gödecke Aktiengesellschaft (DE) 1994-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250161479-A1 TRANSGLUTAMINASE CONJUGATION METHOD AND LINKER TGM3, TGM2, TGM1 GNAI3 2786/4885GNAO1 1653/4885GNAI1 2788/4885
US-12128110-B2 Transglutaminase conjugation method and linker TGM3, TGM2, TGM1 GNAI3 2512/4885GNAO1 1420/4885GNAI1 2579/4885
US-20240350656-A1 TRANSGLUTAMINASE CONJUGATION METHOD AND LINKER TGM3, TGM2, TGM1 GNAI3 2590/4885GNAO1 1504/4885GNAI1 2649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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