Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 7/20 | 0.34 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7613220 | 0.81 | SLC6A2 (0.59) | BCHEACHEMAPTSLC6A2TGFBR1 | |
| Hydrochloric Acid SCHEMBL7610857 | 0.80 | SLC6A2 (0.57) | BCHEACHEMAPTSLC6A2TGFBR1 | |
| SCHEMBL8539198 | 0.77 | SLC6A2 (0.62) | BCHEMAPTSLC6A2 | |
| SCHEMBL8539129 | 0.77 | ROCK1 (0.47) | BCHEACHE | |
| SCHEMBL8546208 | 0.75 | MAPT (0.36) | MAPTSLC6A2 | |
| SCHEMBL8546211 | 0.75 | MAPT (0.35) | BCHEACHEMAPTSLC6A2RPS6KA3 | |
| Hydrochloric Acid SCHEMBL9674029 | 0.74 | MAPT (0.34) | MAPTRPS6KA3 | |
| Hydrochloric Acid SCHEMBL8539622 | 0.74 | MAPT (0.35) | MAPT | |
| SCHEMBL7608055 | 0.66 | TGFBR1 (0.38) | BCHEACHETGFBR1TGFBR2 | |
| SCHEMBL8546204 | 0.65 | SLC6A2 (0.50) | BCHEMAPTSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468401-B1 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-09-16 | — | — | EP | disclosed |
| US-5102891-A | Useful for treating various memory dysfunctions such as alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0468401-A2 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-29 | — | — | EP | disclosed |