Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666751 | 0.84 | GID4 (0.48) | PAX8GID4TNKS2KDM4EMEN1 | |
| SCHEMBL8130957 | 0.83 | GID4 (0.53) | GID4KDM4EMEN1GAAKMT2A | |
| SCHEMBL4001774 | 0.81 | MEN1 (0.52) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL11553849 | 0.79 | MEN1 (0.50) | KDM4EMEN1GAAKMT2AMAPT | |
| SCHEMBL5871368 | 0.78 | PRCP (0.42) | MEN1GAAKMT2AMAPTJAK2 | |
| SCHEMBL11516181 | 0.78 | SLC6A2 (0.44) | — | |
| SCHEMBL8540865 | 0.78 | ESR2 (0.41) | KDM4EMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL8539384 | 0.77 | HTR2C (0.47) | KDM4EMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL11008904 | 0.76 | GID4 (0.40) | GID4KDM4EMEN1GAAKMT2A | |
| SCHEMBL5871406 | 0.74 | PAX8 (0.53) | PAX8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721949-B1 | INDOLINE COMPOUND AND 5-HT 3? RECEPTOR ANTAGONIST CONTAINING THE SAME AS ACTIVE INGREDIENT | TOKYO TANABE CO (JP) | 1998-01-07 | — | — | EP | disclosed |
| US-5677326-A | GASTROINTESTINAL DISORDERS | TOKYO TANABE COMPANY LIMITED (JP) | 1997-10-14 | — | — | US | disclosed |
| EP-0721949-A1 | INDOLINE COMPOUND AND 5-HT 3? RECEPTOR ANTAGONIST CONTAINING THE SAME AS ACTIVE INGREDIENT | TOKYO TANABE COMPANY LIMITED (JP) | 1996-07-17 | — | — | EP | disclosed |